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名稱

Mouse VEGFR3 / FLT-4 Protein/重組小鼠 VEGFR3 / FLT

規(guī)格

20ug

編號

CZDB-008

價格

詢價

中文名

Mouse VEGFR3 / FLT-4 Protein/重組小鼠 VEGFR3 / FLT

分子別稱

Chy, Flt-4, VEGFR-3, VEGFR3

分子種屬

Mouse

表達標(biāo)簽

His，S

表達宿主

E. coli

濃度

> 95 % as determined by SDS-PAGE

緩沖液

Lyophilized from sterile PBS, pH 7.4

存儲條件

-70°C，應(yīng)避免反復(fù)凍融。

基本描述

Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs). The VEGFR3 protein is expressed mainly on lymphatic vessels but it is also up-regulated in tumor angiogenesis. Mutations in VEGFR3 have been identified in patients with primary lymphoedema. The VEGF-C/VEGF-D/VEGFR3 signaling pathway may provide a target for antilymphangiogenic therapy in prostate cancer, breast cancer, gastric cancer, lung cancer, non-small cell lung cancer (NSCLC), and so on.